Anti-Depressants FDA requires all antidepressants to carry a black box warning stating that antidepressants may increase the risk of suicide in persons younger than 25. This warning is based on statistical analyses conducted by two independent groups of the FDA experts that found a 2-fold increase of the suicidal ideation and behavior in children and adolescents, and 1.5-fold increase of suicidality in the 18–24 age group. The suicidality was slightly decreased for those older than 24, and statistically significantly lower in the 65 and older group. Antidepressants may induce mania, mixed states, rapid cycling and/or psychosis in some bipolar patients, particularly if they are not also being treated with a mood stabilizer
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Brand
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Generic
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Manufacturer
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Note
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Prozac
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fluoxetine hydrochloride
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Eli Lilly
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Selective Serotonin Reuptake Inhibitor. May also be used in treatment of OCD, bulimia nervosa, premenstrual dysphoric disorder, and panic disorders.
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Paxil
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paroxetine hydrochloride
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GlaxoSmithKline
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Selective Serotonin Reuptake Inhibitor. May also be used in treatment of generalized anxiety, OCD, panic disorder, social anxiety, PTSD, premenstrual dysphoric disorder, tension headaches. May cause significant weight gain.
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Zoloft
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sertraline hydrochloride
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Pfizer
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Selective Serotonin Reuptake Inhibitor. May also be used in treatment of OCD, panic disorder, social anxiety, PTSD, premenstrual dysphoric disorder
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Celexa
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citalopram
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Forest Lab
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Selective Serotonin Reuptake Inhibitor. May also be used in treatment of anxiety, panic disorder, ADHD, PMDD, Body dysmorphic disorder and OCD
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Strattera
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atomoxetine hyrdrochloride
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Eli Lilly
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Norepinephrine Reuptake Inhibitor. Intended to be an antidepressant; in clinical trials, no such benefits could be proven. Norepinephrine is believed to play a role in ADHD, it was tested-and subsequently approved-as an ADHD treatment. MHRA Drug Safety Update: Associated with treatment-emergent psychotic or manic symptoms in children and adolescents without a history of disorders.
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Luvox
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fluvoxamine maleate
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Abbott
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Selective Serotonin Reuptake Inhibitor (SSRI). May also be used in treatment of anxiety disorders, OCD, post-traumatic stress, and possibly irritable bowel syndrome.
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Lexapro
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escitalopram
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Forest Lab
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Selective Serotonin Reuptake Inhibitor. May also be used in treatment of generalized anxiety disorder, social anxiety disorder, or panic disorder.
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Cymbalta
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duloxetine hydrochloride
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Eli Lilly
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Serotonin-Norepinephrine Reuptake Inhibitor. May also be used in treatment of General Anxiety Disorder, stress urinary incontinence, peripheral neuropathy and fibromyalgia.
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Wellbutrin
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buproprion hydrochloride
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GlaxoSmithKline
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Atypical Antidepressant/Smoking Cessation Aid. May also be used in treatment of ADHD, seasonal affect disorder, weight loss. Lowers seizure threshold/potential to cause seizures.
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Parnate
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tranylcypromine
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GlaxoSmithKline
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Monoamine Oxidase Inhibitor and antianxiety agent. May also be used to treat mood and anxiety disorders
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Tofranil-PM
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imipramine hydrochloride imipramine pamoate
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Covidien-Mallinckrodt
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Tricyclic Antidepressant. May also be used in treatment of enuresis, migraines, ADHD, panic attacks and chronic pain. May cause weight gain.
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Norpramin
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desipramine hydrochloride
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Sanofi-Aventis
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Tricyclic Antidepressant. May also be used in treatment of ADD in children over 6, cocaine withdrawl. FDA warning for healthcare to use caution when prescribing desipramine hydrochloride (Norpramin) in patients with a family history of dysrhythmias or sudden cardiac death.
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Oleptro
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trazodone hydrochloride
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Labopharm
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FDA approved Feb 2010 for treatment of Major Depressive Disorder.
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Effexor
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venlafaxine hydrochloride
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Pfizer
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Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). May also be used in treatment of general anxiety disorder, migraines, OCD, ADHD
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Anafranil
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clomipramine
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Covidien-Mallinckrodt
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Tricyclic-both antidepressant and antiobsessional. May also be used in treatment of OCD.
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Pamelor
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nortriptyline
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Covidien-Mallinckrodt
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Tricyclic Antidepressant. May also be used in treatment of enuresis, chronic fatigue, migraines, panic disorder, irritable bowel syndrome. May reduce symptoms of ADHD
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Emsam
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selegiline transdermal system
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Dey Division of Mylan
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MAO inhibitors. FDA approved for treatment of major depression.
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**generic only
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amoxapine
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Watson Lab
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Tricyclic antidepressant with mild sedative component. Tardive dyskinesia may develop in patients treated with neuroleptic antipsychotic drugs. Amoxapine is not an antipsychotic, but it has substantive neuroleptic activity.
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**generic only
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amitriptyline
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Tricyclic Antidepressant. May also be used in treatment of epilepsy, anxiety, panic disorder, mania in conjunction with another Rx, acute and chronic akathisia induced by antipsychotics.
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**generic only
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maprotiline
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Mylan
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Tetracyclic Antidepressant (TeCA), Antianxiety effects. May also be used in the treatment of bipolar depression, relief of anxiety, tension and insomnia
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Nardil
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phenelzine
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Pfizer
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Monoamine Oxidase Inhibitor (MAOI). Antianxiety properties. May also be used in the treatment of PTSD, treatment resistant depression, dysthymia, bipolar depression, panic disorder, social anxiety disorder, bulimia. Linked to vitamin B6 deficiency.
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Vivactil
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Protriptyline
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Teva
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Tricyclic Antidepressant. May also be used in the treatment of ADHD, narcolepsy, recurrent headaches, panic disorder, enuresis, bulimia, smoking cessation
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Surmontil
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trimipramine
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Odyssey
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Tricyclic Antidepressant. May also be used in the treatment of depression with prominent agitation and anxiety, insomnia, alcohol and opioid withdrawl, chronic pain.
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Marplan
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isocarboxazid
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Validus
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Monoamine Oxidase Inhibitor. May also be used in treatment of resistant depression, social anxiety and panic disorder
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